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I've used both Ad-aware and Spybot Search and Destroy; if one didn't catch something, the other usually did. But these two utils are more for removal after the fact.
In terms of prevention, I don't have any experience with dedicated spyware/adware utils or apps. You should double-check with your anti-virus software (which I hope you already have) because many A/V suites already come with spyware/adware detection.
Paul
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